Expression of concern: Effects of platelet-rich plasma as a new additive on human embryo development and clinical outcomes
Article information
Regarding: Hyun CS, Park MJ, Jang EJ, Kim AN, Yang SH, Hur YS, Gang YJ, Lim JH. Effects of platelet-rich plasma as a new additive on human embryo development and clinical outcomes. Clin Exp Reprod Med. 2025;52(4):367–375. https://doi.org/10.5653/cerm.2025.08228
Concerns have been raised regarding the concentration of platelet-rich plasma (PRP) presented in the above article. The Clinical and Experimental Reproductive Medicine (CERM) Publications Committee reviewed the article and found that the correct concentration was 1% PRP, not 5% PRP, because 50 μL of the recovered PRP supernatant was mixed with 5 mL of culture medium.
The CERM Publications Committee inquired about this concentration issue with the authors and received a letter of explanation. The authors stated that the research was conducted mainly using 1% PRP. However, many reviewers had persistently questioned why 1% PRP was used when other animal studies had used 5% PRP. Moreover, because the clinical pregnancy and implantation rates were similar between the 1% and 5% PRP groups, the authors intentionally reported the concentration as 5% PRP in the article.
The CERM Publications Committee recognized that the concentration was falsely stated and confirmed that the article contains results from both the 1% and 5% PRP groups.
We believe that readers of the journal should be made aware of these issues when accessing this article, and that clinical practice or guidelines should not be based on this report.